Integrated Continuous Manufacturing (ICM)

CONTINUUS Pharmaceuticals’ vision for pharmaceutical manufacturing is that the entire process be integrated into a single end-to-end production line. This was achieved at a pilot scale at the Novartis-MIT Center for Continuous Manufacturing in 2011, as both upstream and downstream components were integrated into a seamless process that was completely automated and run under closed-loop control. This pilot plant was able to demonstrate significant operational advantages over the current batch standard (lead time reduction >90%, plant footprint reduction ~90%, improved quality assurance, and decreased environmental impact). In addition, we project that our Integrated Continuous Manufacturing (ICM) plant will be able to reduce COGS by >50%. In addition to these operational advantages, ICM will be able to provide benefits throughout the supply chain (Figure 1).

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Figure 1. CONTINUUS Pharmaceuticals Offers Significant Advantages Throughout the Supply Chain

To implement ICM lines for our clients, we offer a phased approach whereby their investments can be de-risked. In this way, smaller investments early on will provide compelling results to justify the build-out of a commercial ICM plant. Furthermore, these ICM plants will be able to be located at our facilities or our clients’ facilities; they can be owned by us or our clients; and, they can be operated by our personnel or theirs. Please contact us to see how we can tailor an ICM product that suits your needs.