Continuous Filtration
Precision purification in minutes
CONTINUUS’s continuous filtration system delivers fast, high-efficiency purification of crystallization slurries, removing impurities from APIs and intermediates in just minutes. Designed for seamless integration into an end-to-end Integrated Continuous Manufacturing (ICM) line, the system ensures consistent product quality, enhances solvent recovery, and supports high-containment applications when needed.
A Closer Look at Continuous Filtration
The crystallization slurry is distributed onto a rotating porous plate, where the mother liquor is removed via vacuum filtration. The resulting thin, wet cake (1–6 mm) is passed through multiple modular wash stations that thoroughly purge impurities. After washing, the purified wet cake is transported downstream, while the filter plate is cleaned in line and regenerated for continuous operations. Real-time monitoring of critical process parameters enables effective process control and enhances equipment robustness, sustaining a prolonged state of control.
Key Features of CONTINUUS’s Filtration Technology
- R&D and GMP models, both available with a high containment option for highly potent material
- Short residence time of 1–10 minutes
- Modular wash blocks for effective impurity removal
- Filter media options from 1μm to 10μm
- Built-in data logging for pressure and cake height
- High-containment option for processing potent compounds
- ASME BPE compliant design and built-in CIP capability
- Integration solutions compatible with upstream crystallization and downstream drying units
Modes of Operation
- Delivery of slurry
- Distribution of slurry
- Vacuum filtration
- Washing of wet cake
- Collection of wet cake
- Cleaning of filter plate
Advanced Manufacturing Expertise to Guide Continuous Filtration Process Development
We offer fully comprehensive process development services for all continuous manufacturing unit operations.
Integrated Continuous Manufacturing
/ API
- Flow Chemistry Reaction
- Polish Filtration
- Crystallization
- Solvent Recovery
- Filtration
- Drying
Unit OP Multi-Step
- Extrusion
- Injection Molding
- Coating
Plug-and-Play Unit Operations & Supporting Technologies
CONTINUUS’s modular, plug-and-play unit operations are engineered for seamless integration and rapid configuration and re-configuration. These units can operate as part of a fully integrated ICM line or be implemented individually, enabling flexible deployment tailored to each program’s needs.
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Learn how Integrated Continuous Manufacturing will transform your supply chain by reducing the cost of goods, increasing product quality, enhancing sustainability, and accelerating your path to market.