Crystallization<br />Solutions

Crystallization
Solutions

We have significant expertise converting batch crystallizations to continuous. Through the use of in-line PAT including ReactIR, FBRM, and Raman spectroscopy, we determine the rates of nucleation and crystal-growth to create robust, reliable crystallizations systems.

Our Crystallization solutions

Mixed-Suspension, Mixed-Product Removal (MSMPR) Crystallization: The most simple and general system to perform crystallizations, a multi-stage MSMPR crystallizer is typically utilized to convert batch crystallizations to continuous ones.

Heterogeneous Crystallization: API in different solutions can be crystallized on crystalline or polymeric excipients to eliminate downstream processes such as granulation.

Integrated Nucleator and Tubular Crystallizer: A supersaturated solution is run into a nucleator device containing a specific seed initiating the nucleation process. Particles are then transferred into a tubular (plug flow) crystallizer where growth occurs.

Related Paper

All published articles that relate to this specific technology and solution.

Heterogeneous Crystallization as  a Process Intensification Technology in an  ICM Process for Pharmaceuticals
Heterogeneous Crystallization as a Process Intensification Technology in an ICM Process for Pharmaceuticals
Design and Commercialization of an End-to-End Continuous Pharmaceutical Production Process: A Pilot Plant Case Study
Design and Commercialization of an End-to-End Continuous Pharmaceutical Production Process: A Pilot Plant Case Study
E-factor analysis of a pilot plant for end-to-end integrated continuous manufacturing (ICM) of pharmaceuticals
E-factor analysis of a pilot plant for end-to-end integrated continuous manufacturing (ICM) of pharmaceuticals
Design of a Continuous Solvent Recovery System for End-to-End Integrated Continuous Manufacturing (ICM) of Pharmaceuticals
Design of a Continuous Solvent Recovery System for End-to-End Integrated Continuous Manufacturing (ICM) of Pharmaceuticals
Continuous reactive crystallization of an API in PFR-CSTR cascade with in-line PATs
Continuous reactive crystallization of an API in PFR-CSTR cascade with in-line PATs