Drug product<br />solutions

Drug product
solutions

We have developed proprietary continuous technologies for the manufacturing of pharmaceutical drug products, which are able to be integrated with our upstream continuous processes, as well as the appropriate in-line PATs.

Our DRUg product solution

Extrusion Molding Coating (EMC): Our proprietary Integrated Extrusion-Molding-Coating process produces pharmaceutical-grade coated tablets in a continuous fashion. The API and required excipients are fed into the unit, where they are heated and mixed, resulting in a uniform melt, or extrudate. Coated tablets are then produced as this process material is molded and coated in subsequent sections of the unit. In-line PATs allow for real-time measurement of content uniformity and crystal form. The entire system operates solvent-free.

Thin Film/Electrospinning:Thin Film/Electrospinning: These innovative processes produce solid oral dosage forms directly from solutions of purified API. A solution is processed either through thin-film casting or electroprocessing to produce a thin layer of an API/excipient matrix. The film is subsequently engineered to form tablets of consistent physical dimensions (e.g., thickness, diameter, and mass). All steps are continuous and run in an integrated manner. Our team  has electrospun biological products and demonstrated no loss of structure/function. We believe electrospinning can provide an alternative to the time- and cost-inefficient lyophilization process.

 

Related Paper

All published articles that relate to this specific technology and solution.

Design and Commercialization of an End-to-End Continuous Pharmaceutical Production Process: A Pilot Plant Case Study
Design and Commercialization of an End-to-End Continuous Pharmaceutical Production Process: A Pilot Plant Case Study
E-factor analysis of a pilot plant for end-to-end integrated continuous manufacturing (ICM) of pharmaceuticals
E-factor analysis of a pilot plant for end-to-end integrated continuous manufacturing (ICM) of pharmaceuticals
Design of a Continuous Solvent Recovery System for End-to-End Integrated Continuous Manufacturing (ICM) of Pharmaceuticals
Design of a Continuous Solvent Recovery System for End-to-End Integrated Continuous Manufacturing (ICM) of Pharmaceuticals
An automated modular assembly line for drugs in a miniaturized plant
An automated modular assembly line for drugs in a miniaturized plant