Crystallization<br />Solutions

Crystallization
Solutions

We have significant expertise converting batch crystallizations to continuous. Through the use of in-line PAT including ReactIR, FBRM, and Raman spectroscopy, we determine the rates of nucleation and crystal-growth to create robust, reliable crystallizations systems.

Our Crystallization solutions

Mixed-Suspension, Mixed-Product Removal (MSMPR) Crystallization: The most simple and general system to perform crystallizations, a multi-stage MSMPR crystallizer is typically utilized to convert batch crystallizations to continuous ones.

Heterogeneous Crystallization: API in different solutions can be crystallized on crystalline or polymeric excipients to eliminate downstream processes such as granulation.

Integrated Nucleator and Tubular Crystallizer: A supersaturated solution is run into a nucleator device containing a specific seed initiating the nucleation process. Particles are then transferred into a tubular (plug flow) crystallizer where growth occurs.

Related Paper

All published articles that relate to this specific technology and solution.

Process Development toward the Continuous Manufacturing of Baloxavir Marboxil
Process Development toward the Continuous Manufacturing of Baloxavir Marboxil
Targeting Particle Size Specification in Pharmaceutical Crystallization: A Review on Recent Process Design and Development Strategies and Particle Size Measurements
Targeting Particle Size Specification in Pharmaceutical Crystallization: A Review on Recent Process Design and Development Strategies and Particle Size Measurements
Heterogeneous Crystallization as  a Process Intensification Technology in an  ICM Process for Pharmaceuticals
Heterogeneous Crystallization as a Process Intensification Technology in an ICM Process for Pharmaceuticals
Design and Commercialization of an End-to-End Continuous Pharmaceutical Production Process: A Pilot Plant Case Study
Design and Commercialization of an End-to-End Continuous Pharmaceutical Production Process: A Pilot Plant Case Study
E-factor analysis of a pilot plant for end-to-end integrated continuous manufacturing (ICM) of pharmaceuticals
E-factor analysis of a pilot plant for end-to-end integrated continuous manufacturing (ICM) of pharmaceuticals