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Design of an In-Line pH Neutralization System with Coarse and Fine Adjustments for the Continuous Manufacturing of Pharmaceuticals

Introduction

In-Line pH Neutralization System with Coarse and Fine Adjustments for the Continuous Manufacturing

Abstract

In the continuous manufacturing of pharmaceuticals, in-line monitoring and control are essential. Many pharmaceutical manufacturing processes require pH adjustment. Here, an in-line pH neutralization system with both coarse and fine adjustments was designed, and promising results were obtained. In nonbuffered conditions, the proposed two-pump system was able to control the fluctuations within approximately 2 pH units near the equivalence point, for both aqueous solutions and organic–H2O mixtures with strong acid.

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